منابع مشابه
Lactate and Immunosuppression in Sepsis
Serum lactate levels are traditionally interpreted as a marker of tissue hypoxia and often used clinically as an indicator of severity and outcome of sepsis/septic shock. Interestingly, recent studies involving the effects of tumor-derived lactate suggest that lactate itself may have an immunosuppressive effect in its local environment. This finding adds to the recent advances in immunometaboli...
متن کاملPotential Immunotherapeutics for Immunosuppression in Sepsis
Sepsis is a syndrome characterized by systemic inflammatory responses to a severe infection. Acute hyper-inflammatory reactions in the acute phase of sepsis have been considered as a primary reason for organ dysfunction and mortality, and advances in emergency intervention and improved intensive care management have reduced mortalities in the early phase. However it has been recognized that inc...
متن کاملLactate – a Marker for Sepsis and Trauma
It is our pleasure to provide this EMCREG International newsletter which discusses lactate as a marker in resuscitation for sepsis and trauma. While lactate testing has been in medical arena for over a century, its utility in the emergency department for the evaluation of these potentially critically ill patients is only now being recognized. This newsletter aims to review the present literatur...
متن کاملSepsis, lactate, and oxygen supply dependence.
www.chestpubs.org 2 . Bouros D , Wells AU , Nicholson AG , et al . Histopathologic subsets of fi brosing alveolitis in patients with systemic sclerosis and their relationship to outcome . Am J Respir Crit Care Med . 2002 ; 165 ( 12 ): 1581 1586 . 3 . Betteridge ZE , Gunawardena H , McHugh NJ . Novel autoantibodies and clinical phenotypes in adult and juvenile myositis . Arthritis Res Ther . 201...
متن کاملReconsidering lactate as a sepsis risk biomarker
OBJECTIVES There has been renewed interest in lactate as a risk biomarker in sepsis and septic shock. However, the ability of the odds ratio (OR) and change in the area under the receiver operator characteristic curve (AUC-ROC) to assess biomarker added-value has been questioned. DESIGN, SETTING AND PARTICIPANTS A sepsis cohort was identified from the ICU database of an Australian tertiary re...
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ژورنال
عنوان ژورنال: Shock
سال: 2018
ISSN: 1073-2322,1540-0514
DOI: 10.1097/shk.0000000000000958